張榮叁 教授

聯絡方式

• 校內分機：2645 #83
• 郵件信箱：cjs@kmu.edu.tw

現任

• 高雄醫學大學腎臟照護學系教授
• 高雄醫學大學附設中和紀念醫院胃腸內科主治醫師

學經歷

• 高雄醫學院醫學士
• 高雄醫學大學醫學研究所博士
• 中華醫事科技大學醫務管理系助理教授
• 高雄醫學大學藥學院臨床藥學研究所助理教授
• 美國國家衛生研究院(NIH)訪問學者
• 文雄醫院胃腸肝膽科主任、加護病房主任、內科部主任

專書

(1).    Jung San Chang and Hung Chun Chen. Dengue and other viral haemorrhagic fevers. In: Turner, N., Lameire, N., Goldsmith, D.J., Winearls, C.G., Himmelfarb, J., and Remuzzi, G., (Eds). Oxford Textbook of Clinical Nephrology. Fourth Edition. New York: Oxford University Press; 2015. Chapter 189.

(2).    Jan Clement, Jung-San Chang, Hung-Chun Chen, and Piet Maes. In: Turner, N., Lameire, N., Goldsmith, D.J., Winearls, C.G., Himmelfarb, J., and Remuzzi, G., (Eds). Oxford Textbook of Clinical Nephrology. Fourth Edition. New York: Oxford University Press; 2015. Chapter 188.

研究論文

1.     SCI Journals

(1).    Chien HT, Lin YC, Sheu CC, Hsieh KP, Chang JS*. Is Colistin-associated Acute Kidney Injury Important in Adults? A Systematic Review and Meta-analysis. Int J Antimicrob Agents. 2020 (Jan 8:105889. doi: 10.1016/j.ijantimicag.2020.105889.) 55: 105889

(2).     Eng YS, Lee CH, Lee WC, Huang CC, Chang JS*. Unraveling the Molecular Mechanism of Traditional Chinese Medicine: Formulas Against Acute Airway Viral Infections as Examples. Molecules 2019, 24, 3505; doi:10.3390/molecules24193505.

(3).     Lin FL, Yeh ML, Lai YH, Lin KC, Yu CJ, Chang JS. Two-month breathing-based walking improves anxiety, depression, dyspnea, and quality of life in chronic obstructive pulmonary disease: a randomized controlled study. Journal of Clinical Nursing. J Clin Nurs. 2019 Oct;28(19-20):3632-3640.

(4).    Lin YH, Liang CJ, Liu MC, Huang MF, Chang JS, Liang SS. The use of chemical probes to detect the proteomics of renal tubular injury induced by maleic acid. Journal of Chromatography A, 1565 (2018) 96–104

(5).    Lin TJ, Huang YL, Chang JS, Liu KT, Yen MC, Chen FW, Shih YL, Jao JC, Huang PC, Yeh IJ. Optimal dosage and early intervention of L-ascorbic acid inhibiting K2Cr2O7- induced renal tubular cell damage. Journal of Trace Elements in Medicine and Biology 48 (2018) 1–7

(6).    Yen MH, Huang CI, Lee MS, Cheng YP, Hsieh CJ, Chiang LC, Chang JS*. Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization. Kaohsiung J Med Sci. 2018 Mar;34(3):150-159.

(7).    Chiang YW, Yeh CF,Yen MH, Lu CY, Chiang LC, Shieh DE, Chang JS*. Flos Farfarae inhibited Enterovirus 71-induced cell injury by inhibiting viral replication and structure protein expression. Am. J. Chin. Med. 2017 Feb; 45(2):299-317.

(8).     Huang SF, Chang JS, Sheu CC, Liu YT, Lin YC*. An Antibiotic Decision-Making Tool for Patients With Pneumonia Admitted to the Medical Intensive Center Unit.Int J Antimicrob Ag. 2016 Sep; 48(3): 286–291

(9).     Hsieh YJ,Yen MH,Chiang YW,Yeh CF,Chiang LC,Shieh DE,Yeh IJ,Chang JS*. Gan-Lu-Siao-Du-yin, a prescription of traditional Chinese medicine, inhibited enterovirus 71 replication, translation, and virus-induced cell apoptosis. J Ethnopharmacol.2016 Jun 5;185:132-139.

(10).Lin MY, Chiu YW, Chang JS, Lin HL, Lee CT, Chiu GF, Kuo MC, Wu MT, Chen HC, Hwang SJ. Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease.KidneyInt. 2015 Aug 5. doi: 10.1038/ki.2015.226.

(11).Yeh CF, Wang KC, Lu CY, Chiang LC, Shieh DE, Yen MH, Chang JS*. Yakammaotoinhibits enterovirus 71 infection with reduced viral attachment,internalization, replication, and translation. Kaohsiung J Med Sci 2015 Jun; 31(6): 293-302.

(12).Liu YM, Chung YC, Chang JS, Yeh ML. Effects of aerobic exercise during hemodialysis on physical functional performance and depression. Biological Research for Nursing.(Biol Res Nurs.)2015 Mar; 17(2): 214-21. doi: 10.1177/1099800414539548.

(13).Lee JJ,Lin MY,Chang JS,Hung CC,Chang JM,Chen HC,Yu ML,Hwang SJ. Hepatitis C Virus Infection Increases Risk of Developing End-Stage Renal Disease Using Competing Risk Analysis. PLoS One.2014 Jun 27; 9(6):e100790. doi: 10.1371/journal.pone.0100790. eCollection 2014.

(14).Yen MH, Lee JJ, Yeh CF,Wang KC, Chiang YW, Chiang LC, Chang JS*. Yakammaoto inhibited human coxsackievirus B4 (CVB4)-induced airway and renal tubular injuries by preventing viral attachment, internalization, and replication.J Ethnopharmacol2014 Feb 12; 151 (3): 1056–1063

(15).Lin TJ, Yeh CF, Wang KC, Chiang LC, Tsai JJ, Chang JS*.Water extract of Pueraria lobata Ohwi has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Kaohsiung J Med Sci 2013 Dec; 29 (12): 651-657.

(16).Yeh CF,Wang KC, Chiang LC, Shieh DE, Yen MH, Chang JS*. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol2013 July 9; 148 (2): 466–473

(17).Yeh CF,Chang JS, Wang KC, Shieh DE, Chiang LC. Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation. J Ethnopharmacol2013 May 20;147(2):321-6.

(18).Chang JS, Yeh CF,Wang KC, Shieh DE, Yen MH, Chiang LC. Xiao-Qing-Long-Tang (Sho-Seiryu-To) inhibited cytopathic effect ofhuman respiratory syncytial virus in cell lines of human respiratory tract.J Ethnopharmacol2013 May 20;147(2):481-7.

(19).Lin TJ, Wang KC, Lin CC, Chiang LC, Chang JS*. Anti-viral activity of water extract of Paeonia lactiflora Pallas against human respiratory syncytial virus in human respiratory tract cell lines. Am. J. Chin. Med. 2013;41(3):585-99. (May-June)

(20).Chang JS, Wang KC, Yeh CF, Shieh DE, Hsu FF, Chiang LC. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines.J Ethnopharmacol2013 Jan 9; 145 (1): 146–151

(21).Chang JS,Wang KC, Shieh DE, Hsu FF, Chiang LC. Ge-Gen-Tang has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol2012 Jan 6; 139 (1): 305– 310.

(22).Wang KC, Chang JS, Lin LT, Chiang LC, Lin CC. Antiviral effect of cimicifugin from Cimicifuga foetidaagainst human respiratory syncytial virus. Am. J Chin. Med. 2012;40(5):1033-45.

(23).Wang KC, Chang JS, Chiang LC, Lin CC. Cimicifuga foetida L. inhibited human respiratory syncytial virus in HEp-2 and A549 cell lines. Am. J. Chin. Med. 40(1):151-62, 2012.

(24).Chang JS,Wang KC, Shieh DE, Chiang LC. Liu-He-Tang inhibited plaque formation byhuman respiratory syncytial virus infection in cell lines of the human respiratory tract. J Ethnopharmacol2011 Oct 11; 137 (3):1149– 1155.

(25).Chuang HY, Ng LT, Lin LT, Chang JS, Chen JY, Lin TC, Lin CC. Hydrolysable tannins of tropical almond show antifibrotic effects in the TGF-β1-induced hepatic stellate cells. Journal of the Science of Food and Agriculture.J Sci Food Agric. 91(15) 2777-2784, 2011

(26).Wang KC, Chang JS, Chiang LC, Lin CC. Sheng-Ma-Ge-Gen-Tang (Shoma-kakkon-to) inhibited cytopathic effect of human respiratory syncytial virus in cell lines of human respiratory tract. J Ethnopharmacol 2011 May 17; 135(2): 538-44.

(27).Tsai JJ, Jen YH, Chang JS, Hsiao HM, Noisakran S, Perng GC. Frequency Alterations in Key Innate Immune Cell Components in the Peripheral Blood of Dengue Patients Detected by FACS Analysis. J Innate Immun. 2011; 3(5):530-40.

(28).McLellan JS, Chen M, Chang JS, Yang Y, Kim A, Graham BS, Kwong PD. Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F. J Virol. 2010 Dec;84(23):12236-44.

(29).Chen M, Chang JS, Nason M, Rangel D, Gall JG, Graham BS, Ledgerwood JE. A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate. J Immunol Methods. 2010 Oct 31;362(1-2):180-4.

(30).Chan KS, Chang JS, Chang K, Lin CC, Huang JH, Lin WR, Chen TC, Hsieh HC, Lin SH, Lin JC, Lu PL, Chen YH, Lin CY, Tsai JJ. Effect of serotypes on clinical manifestations of dengue fever in adults. J Microbiol Immunol Infect. 2009 Dec;42(6):471-8.

(31).Wang KC, Chang JS, Chiang LC, Lin CC. 4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line.Phytomedicine. 2009 Sep;16(9):882-6.

(32).Kuo KK, Chang JS, Wang KC, Chiang LC. Water extract of Glycyrrhiza uralensis inhitibed Enterovirus 71 in a humanforeskin fibroblast cell line. Am. J Chin. Med. 2009;37(2):383-94.

(33).Su FM, Chang JS, Wang KC, Tsai JJ, Chiang LC. Water extract of Pueraria lobata inhibited cytotoxicity of Enterovirus 71 in human foreskin fibroblast cell line. Kaohsiung J Med Sci 24(10):523-529, 2008.

(34).Lin TJ, Walter FG, Hung DZ, Tsai JL, Hu SC, Chang JS,Deng JF, Denninghoff K, Chase PB, Chan HM. Epidemiology of organophosphate pesticidepoisoning in Taiwan. Clin Toxicol (Phila). 2008 Jun 14:1-8.  

(35).Chang JS, Wang KC, Chiang LC. Sheng-Ma-Ge-Gen-Tang inhibited Enterovirus 71 infection in human foreskin fibroblast cell line. J Ethnopharmacol 2008 Sep 2;119(1):104-108.

(36).Chang JS, Wang KC, Liu HW, Chen MC, Chiang LC, Lin CC. Sho-saiko-to (Xiano-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line. Am. J Chin. Med. 35(2): 341–351, 2007  

(37).Chang JS, Liu HW, Wang KC, Hua YC, Chiang LC, Lin CC. Ethanol extract of Polygonum cuspidatum inhibit hepatitis B virus in a stable HBV-producing cell line. Antiviral Res. 66(1): 29-34, 2005.  

(38).Chang JS, Hsu YL, Kuo PL, Kuo YJ, Chiang LC, Lin CC. Increase of Bax/ Bcl-XL ratio and Arrest of Cell Cycle by Luteolin in Immortalized Human Hepatoma cell line. Life Sci. 76(16): 1883-1893, 2005.  

(39).Chang JS, Chiang LC, Hsu FF, Lin CC. Chemoprevention of Cornus officinalis against Hepatocellular Carcinoma in vitro. Am. J Chin. Med. 32(5):717-725, 2004.

(40).Chang JS, Hsu YL Kuo PL, Chiang LC, Lin CC. Upregulation of Fas/FasL mediated apoptosis by gossypol in immortalized human lung cancer cell line. Clin Exp Pharmacol Physiol 31:716-722,

(41).Chiang LC, Chang JS, Chen CC, Ng LT, Lin CC. Anti-Herpes simplex virus activity of Bidens pilosa and Houttuynia cordata. Am. J Chin. Med. 31(3): 355-362, 2003.

(42).Chang JS, Chiang LC, Chen CC, Liu LT, Wang KC, Lin CC. Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. Am. J Chin. Med. 29(2): 303-312, 2001.

(43).Chang JS, Chen SC, Chuang WL, Wang LY, Chang WY. Paraumbilical vein tumor thrombosis in hepatocellular carcinoma. Am. J Gastroenterol. 89(7): 1099-1102, 1994.